|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 22.214.171.124
Enzymes and Genes:
|Escherichia coli K-12 substr. MG1655 :||alkaline phosphatase
acid phosphatase / phosphotransferase : aphA
broad specificity 5'(3')-nucleotidase and polyphosphatase : umpG
pyrimidine nucleotidase : yjjG
UMP phosphatase : umpH
5'-ribonucleotidase : ushA
|Homo sapiens :||5'-nucleotidase
cytosolic 5'-nucleotidase 1A : NT5C1A
|Solanum tuberosum :||5'-nucleotidase
In Pathway: adenosine nucleotides degradation II
Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .
Reaction Locations: periplasmic space (sensu Gram-negative Bacteria), cytosol
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Mass balance status: Balanced.
Enzyme Commission Primary Name: 5′-nucleotidase
Enzyme Commission Synonyms: uridine 5'-nucleotidase, 5'-adenylic phosphatase, adenosine 5'-phosphatase, AMP phosphatase, adenosine monophosphatase, 5'-mononucleotidase, AMPase, UMPase, snake venom 5'-nucleotidase, thimidine monophosphate nucleotidase, 5'-AMPase, 5'-AMP nucleotidase, AMP phosphohydrolase, IMP 5'-nucleotidase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 6.127014 [Latendresse13]
Enzyme Commission Summary:
Wide specificity for 5-nucleotides.
Instance reaction of [a ribonucleoside 5'-monophosphate + H2O → a ribonucleoside + phosphate] (126.96.36.199):
i1: AMP + H2O → adenosine + phosphate (188.8.131.52)
Relationship Links: BRENDA:EC:184.108.40.206 , ENZYME:EC:220.127.116.11 , IUBMB-ExplorEnz:EC:18.104.22.168 , UniProt:RELATED-TO:O29385 , UniProt:RELATED-TO:O34313 , UniProt:RELATED-TO:O83142 , UniProt:RELATED-TO:P06196 , UniProt:RELATED-TO:P07024 , UniProt:RELATED-TO:P21588 , UniProt:RELATED-TO:P21589 , UniProt:RELATED-TO:P22848 , UniProt:RELATED-TO:P29240 , UniProt:RELATED-TO:P44569 , UniProt:RELATED-TO:P49902 , UniProt:RELATED-TO:Q9KM44 , UniProt:RELATED-TO:Q05927
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