|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 22.214.171.124
Enzymes and Genes:
|Escherichia coli K-12 substr. MG1655:||alkaline phosphatase: phoA|
pyrimidine nucleotidase: yjjG
UMP phosphatase: umpH
broad specificity 5'(3')-nucleotidase and polyphosphatase: umpG
acid phosphatase / phosphotransferase: aphA
|Homo sapiens:||5'-nucleotidase: NT5E|
cytosolic 5'-nucleotidase 1A: NT5C1A
In Pathway: adenosine nucleotides degradation II
Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .
Reaction Locations: periplasm (sensu Gram-negative Bacteria), cytosol
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Mass balance status: Balanced.
Enzyme Commission Primary Name: 5′-nucleotidase
Enzyme Commission Synonyms: uridine 5'-nucleotidase, 5'-adenylic phosphatase, adenosine 5'-phosphatase, AMP phosphatase, adenosine monophosphatase, 5'-mononucleotidase, AMPase, UMPase, snake venom 5'-nucleotidase, thimidine monophosphate nucleotidase, 5'-AMPase, 5'-AMP nucleotidase, AMP phosphohydrolase, IMP 5'-nucleotidase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 6.127014 [Latendresse13]
Enzyme Commission Summary:
Wide specificity for 5-nucleotides.
Instance reaction of [a ribonucleoside 5'-monophosphate + H2O → a ribonucleoside + phosphate] (126.96.36.199):
i1: AMP + H2O → adenosine + phosphate (188.8.131.52)
Relationship Links: BRENDA:EC:184.108.40.206, ENZYME:EC:220.127.116.11, IUBMB-ExplorEnz:EC:18.104.22.168, UniProt:RELATED-TO:O29385, UniProt:RELATED-TO:O34313, UniProt:RELATED-TO:O83142, UniProt:RELATED-TO:P06196, UniProt:RELATED-TO:P07024, UniProt:RELATED-TO:P21588, UniProt:RELATED-TO:P21589, UniProt:RELATED-TO:P22848, UniProt:RELATED-TO:P29240, UniProt:RELATED-TO:P44569, UniProt:RELATED-TO:P49902, UniProt:RELATED-TO:Q9KM44, UniProt:RELATED-TO:Q05927
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