Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 4.1.1.32

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.1.1.32

Enzymes and Genes:
phosphoenolpyruvate carboxykinase Inferred from experiment : PEPCK ( Ascaris suum )
phosphoenolpyruvate carboxykinase Inferred from experiment : JN595866 ( Mytilus galloprovincialis )
phosphoenolpyruvate carboxykinase [GTP], mitochondrial : PCK2 ( Homo sapiens )
phosphoenolpyruvate carboxykinase, cytosolic [GTP] Traceable author statement to experimental support : PCK1 ( Homo sapiens )

In Pathway: gluconeogenesis III , anaerobic energy metabolism (invertebrates, cytosol)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phosphoenolpyruvate carboxykinase (GTP)

Enzyme Commission Synonyms: phosphoenolpyruvate carboxylase, phosphopyruvate carboxylase, phosphopyruvate (guanosine triphosphate) carboxykinase, phosphoenolpyruvic carboxykinase (GTP), phosphopyruvate carboxylase (GTP), phosphoenolpyruvic carboxylase (GTP), phosphoenolpyruvic carboxykinase, phosphoenolpyruvate carboxykinase, PEP carboxylase, GTP:oxaloacetate carboxy-lyase (transphosphorylating)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -102.00592 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
ITP can act as phosphate donor.

Citations: [KURAHASHI57, Chang66]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R00431 , Rhea:10388

Relationship Links: BRENDA:EC:4.1.1.32 , ENZYME:EC:4.1.1.32 , IUBMB-ExplorEnz:EC:4.1.1.32 , UniProt:RELATED-TO:P05153 , UniProt:RELATED-TO:P07379 , UniProt:RELATED-TO:P20007 , UniProt:RELATED-TO:P21642 , UniProt:RELATED-TO:P22130 , UniProt:RELATED-TO:P29190 , UniProt:RELATED-TO:P35558 , UniProt:RELATED-TO:Q16822


References

Chang66: Chang HC, Lane MD (1966). "The enzymatic carboxylation of phosphoenolpyruvate. II. Purification and properties of liver mitochondrial phosphoenolpyruvate carboxykinase." J Biol Chem 241(10);2413-20. PMID: 5911620

KURAHASHI57: KURAHASHI K, PENNINGTON RJ, UTTER MF (1957). "Nucleotide specificity of oxalacetic carboxylase." J Biol Chem 226(2);1059-75. PMID: 13438893

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Dec 21, 2014, BIOCYC14A.