MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Ascaris suum: phosphoenolpyruvate carboxykinaseInferred from experiment: PEPCK
Homo sapiens: phosphoenolpyruvate carboxykinase, cytosolic [GTP]Traceable author statement to experimental support: PCK1
phosphoenolpyruvate carboxykinase [GTP], mitochondrial: PCK2
Mytilus galloprovincialis: phosphoenolpyruvate carboxykinaseInferred from experiment: JN595866

In Pathway: gluconeogenesis III, anaerobic energy metabolism (invertebrates, cytosol)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phosphoenolpyruvate carboxykinase (GTP)

Enzyme Commission Synonyms: phosphoenolpyruvate carboxylase, phosphopyruvate carboxylase, phosphopyruvate (guanosine triphosphate) carboxykinase, phosphoenolpyruvic carboxykinase (GTP), phosphopyruvate carboxylase (GTP), phosphoenolpyruvic carboxylase (GTP), phosphoenolpyruvic carboxykinase, phosphoenolpyruvate carboxykinase, PEP carboxylase, GTP:oxaloacetate carboxy-lyase (transphosphorylating)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -102.00592Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
ITP can act as phosphate donor.

Citations: [KURAHASHI57 , Chang66]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R00431, Rhea:10388

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:P05153, UniProt:RELATED-TO:P07379, UniProt:RELATED-TO:P20007, UniProt:RELATED-TO:P21642, UniProt:RELATED-TO:P22130, UniProt:RELATED-TO:P29190, UniProt:RELATED-TO:P35558, UniProt:RELATED-TO:Q16822


Chang66: Chang HC, Lane MD (1966). "The enzymatic carboxylation of phosphoenolpyruvate. II. Purification and properties of liver mitochondrial phosphoenolpyruvate carboxykinase." J Biol Chem 241(10);2413-20. PMID: 5911620

KURAHASHI57: KURAHASHI K, PENNINGTON RJ, UTTER MF (1957). "Nucleotide specificity of oxalacetic carboxylase." J Biol Chem 226(2);1059-75. PMID: 13438893

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Tue Nov 24, 2015, BIOCYC13B.